ArticleEuropean heart journal. Imaging methods and practice2026
Cardiac energetics in health and disease: a meta-analysis.
Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Aims: The cardiac phosphocreatine-to-ATP ratio (PCr/ATP) is the principal non-invasive biomarker of myocardial energetic status and is measured by phosphorus magnetic resonance spectroscopy ( Methods and results: Here, we use systematic review and meta-analysis of all available studies reporting cardiac PCr/ATP ratios to show pooled reference values across populations (databases searched: Embase, Medline, CENTRAL). We collected data on differing methodological factors to enable adjustment. We included 176 studies comprising 7843 individual participant magnetic resonance examinations between 1987 and 2025. The pooled PCr/ATP ratio was 1.96 for healthy volunteers ( Conclusion: This comprehensive meta-analysis provides reference PCr/ATP values across cardiac conditions, implicating energetic impairment as a common pathway spanning myocardial diseases of diverse aetiology, and suggests that methodological heterogeneity does not fully account for the observed between-group differences. Registration: PROSPERO (CRD420251081946).
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