Evidence map›Paper›PMID 42422326›Full record

ArticleASPET discovery2025

Targeting ribonucleotide reductase to enhance the antileukemic activity of gilteritinib against chemoresistant

Nibal Eid, Jianlei Zhao, Jenna Thibodeau, Holly Edwards, Jing Li, Xun Bao, Lisa Polin, Juiwanna Kushner, Sijana H Dzinic, Kathryn White and 7 more

Abstract read
In one paragraph

Article in ASPET discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nibal EidPediatric Hematology/Oncology Fellowship Program, Children's Hospital of Michigan, Detroit, Michigan.ORCID https://orcid.org/0009-0006-7706-4784
Jianlei ZhaoMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Jenna ThibodeauCancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, Michigan.
Holly EdwardsMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Jing LiMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Xun BaoMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.ORCID https://orcid.org/0000-0003-4895-8536
Lisa PolinMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Juiwanna KushnerMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Sijana H DzinicMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Kathryn WhiteMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Steven A BuckDivision of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan.
Jessica B BackDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Paul M StemmerTumor Biology and Microenvironment Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Maurgan LeeInstitute of Environmental Health Sciences and Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan.ORCID https://orcid.org/0009-0004-1716-0913
Seongho KimMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.ORCID https://orcid.org/0000-0003-1120-073X
Jeffrey W TaubMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Yubin GeMolecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
Translational Research Support CoreP30ES036084 · NIEHS · WAYNE STATE UNIVERSITY · PI Melissa A Runge-Morris · 2024 to 2026
$5.2M
Orbitrap Tribrid Mass Spectrometer for Wayne State ProteomicsS10OD030484 · OD · WAYNE STATE UNIVERSITY · PI STEMMER, PAUL M · 2021 to 2021
$1.3M
NCI NIH HHS P30 CA022453NIEHS NIH HHS P30 ES036084NIH HHS S10 OD030484
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) cases harboring

Indexed as

Acute myeloid leukemiaCytarabine-resistantFMS-like tyrosine kinase 3-internal tandem duplicationGilteritinibHydroxyurea

Identifiers

PMID42422326
PMCPMC13344374

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.