ReviewBiology of sport2026
The impact of maximal fat oxidation intensity exercise on glucose and lipid metabolism in individuals with overweight or obesity: A systematic review and meta-analysis.
Review in Biology of sport, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
This study provides the first quantitative synthesis evaluating the chronic effects of FATmax training on glucose and lipid metabolism in individuals with overweight or obesity, while systematically exploring the moderating roles of participant characteristics and intervention protocols. A comprehensive search of seven databases (e.g., PubMed, Web of Science) was conducted up to August 2025, identifying 24 controlled trials involving 638 participants. Random-effects meta-analyses showed that FATmax training produced significant improvements in multiple glycolipid metabolic markers. Specifically, large standardized reductions were observed in fasting plasma glucose (Hedges' g = -1.05), insulin resistance (Hedges' g = -0.82), and fasting insulin (Hedges' g = -0.75), alongside moderate improvements in triglycerides (Hedges' g = -0.55), total cholesterol (Hedges' g = -0.23), and high-density lipoprotein cholesterol (HDL-C; Hedges' g = 0.51). Notably, the large standardized effects on glycemic markers suggest potentially clinically meaningful improvements in glycemic control. Subgroup analyses indicated that HDL-C adaptations were significantly enhanced in male participants, weight-bearing modalities, and protocols incorporating warm-up sessions or concurrent dietary restriction (p < 0.05). Furthermore, meta-regression identified baseline HDL-C (β= -2.955), exercise intensity (β = 0.053), and session duration (β = 0.058) as significant predictors of HDL-C improvement. Crucially, we derive the first clinically actionable, personalized thresholds from interaction analyses: for individuals with low baseline HDL-C (≤ 1.36 mmol/L), efficacy is maximized when session duration exceeds 60 minutes (Hedges' g = 1.19) or intensity surpasses 42.2%
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