ArticleFrontiers in endocrinology2026
Joint effects of severe obesity and inflammation on mortality in critically ill non-ST-segment elevation myocardial infarction patients: a cohort study with external validation.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To investigate the association between body mass index (BMI) and both in-hospital and 10-year all-cause mortality in critically ill non-ST-segment elevation myocardial infarction (NSTEMI) patients, and to evaluate the incremental value of C-reactive protein (CRP) in risk stratification. Methods: This multinational study included 7,815 critically ill NSTEMI patients from three cohorts. We first analyzed an original discovery cohort (TAMI, n = 5,010) from a Chinese tertiary hospital, then externally validated the findings in two independent US cohorts (MIMIC-IV, n = 1,208; eICU-CRD, n = 1,597). BMI was categorized according to WHO criteria, and CRP was dichotomized at 2 mg/L. Multivariable Cox regression and restricted cubic splines were used to assess mortality risks. Results: In the TAMI cohort, severe obesity (BMI ≥ 35 kg/m Conclusions: BMI exhibits a U-shaped association with mortality in critically ill NSTEMI patients. Severe obesity combined with elevated inflammation identifies a high-risk clinical profile, supporting integrated metabolic-inflammatory risk stratification.
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