ReviewFrontiers in pediatrics2026
The therapeutic potential of natural products for pediatric psoriasis: targeting the immune microenvironment.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoriasis is a chronic, recurrent, inflammatory skin disorder closely associated with dysregulation of the immune microenvironment. Conventional systemic therapies often face limitations in children due to safety concerns, highlighting the urgent need for safer and effective treatment options. Natural products, characterized by their multi-target and multi-pathway actions along with relatively favorable safety profiles, as suggested primarily by adult and preclinical studies, have shown great potential in modulating the immune microenvironment. This review summarizes recent advances in the use of natural products-including plant extracts, active components, and compound formulations-in reshaping the immune microenvironment of psoriatic lesions by regulating T cell subsets, cytokine networks, innate immune cell functions, and skin barrier integrity. We explicitly distinguish between evidence derived from pediatric clinical studies, adult studies, and preclinical models. Furthermore, the article explores the implications of these findings for developing novel therapeutic strategies specifically tailored for pediatric psoriasis, addressing current challenges, and outlining future directions for translational research. By integrating these insights, this review aims to provide a comprehensive understanding of how natural products can contribute to safer and more effective immunomodulatory treatments in children with psoriasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.