Evidence map›Paper›PMID 42422469›Full record

ReviewClinical hypertension2026

Hypertension in chronic kidney disease: where do international guidelines converge and diverge?

Emelina Stambolliu, Elpiniki Stathopoulou, Margarita Bora, Aikaterini Damianaki

Abstract readReview
In one paragraph

Review in Clinical hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emelina StambolliuNephrology Department, Hippokration General Hospital, Athens, Greece.ORCID https://orcid.org/0000-0002-3701-7004
Elpiniki StathopoulouNephrology Department, Hippokration General Hospital, Athens, Greece.
Margarita BoraUCL Centre for Nephrology, Royal Free Hospital, University College London Medical School, London, UK.
Aikaterini DamianakiNephrology Department, Hippokration General Hospital, Athens, Greece.ORCID https://orcid.org/0000-0003-2815-3650

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, major scientific societies have updated their hypertension guidelines, each incorporating specific recommendations for patients with chronic kidney disease (CKD). Across societies, there is strong consensus on standardized office and out-of-office blood pressure (BP) measurement, as well as systematic assessment of estimated glomerular filtration rate and albuminuria, with confirmation of abnormalities and regular monitoring. Moderate-to-severe CKD is universally recognized as a major determinant of cardiovascular (CV) risk and is frequently considered equivalent to established CV disease, thereby supporting earlier and more intensive BP treatment. Although BP thresholds for treatment initiation and on-treatment BP targets remain debated, there is broad agreement on the preferential use of dual-agent combination therapy, including surely renin-angiotensin system inhibitors in patients with albuminuric CKD-together with calcium-channel blockers or diuretics, with diuretic selection largely guided by renal function. Moreover, contemporary guidelines increasingly emphasize disease-modifying strategies, including sodium-glucose cotransporter 2 inhibitors and nonsteroidal mineralocorticoid receptor antagonists in selected patients, to improve cardio-renal outcomes. Despite differences in definitions, targets, and treatment algorithms, all guidelines converge on a patient-centered approach prioritizing cardio-renal protection, adherence, and individualized care. With this review, we summarize and compare key recommendations for patients with CKD from the 2023 European Society of Hypertension (ESH), the 2024 European Society of Cardiology, the 2021 Kidney Disease: Improving Global Outcomes, and the 2025 American Heart Association/American College of Cardiology guidelines, with the aim of supporting clinicians in navigating guideline complexity and optimizing hypertension management in CKD.

Indexed as

Antihypertensive therapyBlood pressure targetsChronic kidney diseaseGuidelinesHypertension

Identifiers

PMID42422469
PMCPMC13341566

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.