Evidence map›Paper›PMID 42422595›Full record

ArticleWorld journal of pediatric surgery2026

Encapsulation enhances stromal cell survival for safe neonatal therapy: a pilot study.

Jasmine Lee, Kelly Henige, Fikir Mesfin, Sharon Joseph, Krishna Manohar, Chris Shelley, Jianyun Liu, Minglin Ma, Minseok Lee, Troy Markel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of pediatric surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jasmine LeeDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kelly HenigeDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Fikir MesfinDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sharon JosephDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Krishna ManoharDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Chris ShelleyDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jianyun LiuDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Minglin MaDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA.
Minseok LeeDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA.ORCID https://orcid.org/0000-0002-9180-7699
Troy MarkelDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-6429-2976

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mesenchymal stromal cells (MSCs) have demonstrated therapeutic benefit in preclinical models of necrotizing enterocolitis (NEC), yet clinical translation remains limited by concerns about immune clearance and tumorigenic risk. Encapsulation strategies offer a potential solution by limiting systemic exposure while preserving efficacy. We hypothesized that encapsulation of MSCs would improve cell survival and maintain cell identity in this proof-of-concept study. Methods: Luciferase-expressing MSCs were generated via lentiviral transduction and validated for luminescence. Mice received MSCs either intraperitoneally ( Results: The bioluminescent signal declined in both groups, but MSCs delivered in the THRED retained significantly greater viability on day 4 ( Conclusion: Encapsulation within the THRED preserves MSC viability and identity

Indexed as

Animal ExperimentationCell BiologyNeonatology

Identifiers

PMID42422595
PMCPMC13343122

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.