ArticleFrontiers in medicine2026
Case Report: Metastatic pancreatic ductal adenocarcinoma initially masked by multiple gastroduodenal ulcers with apparent endoscopic healing: a diagnostic pitfall.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at an advanced stage because its early manifestations are nonspecific and may mimic benign gastrointestinal disorders. When multifocal gastroduodenal ulcers show benign histology and apparent healing after acid-suppressive therapy, the diagnostic impression may be misleading and delay recognition of an underlying malignancy. Case presentation: A 69-year-old man presented with intermittent epigastric discomfort for 1 month. Upper gastrointestinal endoscopy revealed multiple ulcerative lesions involving the esophagus, stomach, and duodenum. Repeated biopsies showed only chronic inflammatory changes without dysplasia or malignancy. Management and outcome: The patient was treated with high-dose vonoprazan (20 mg, bid, p.o.), and follow-up endoscopy demonstrated complete or near-complete healing of the ulcers. However, despite this favorable endoscopic response, the etiology of the extensive multifocal ulceration remained unexplained. Because this persistent diagnostic uncertainty was accompanied by ongoing symptoms and progressively rising carbohydrate antigen 19-9 (CA19-9) levels, further cross-sectional imaging was performed. Computed tomography and magnetic resonance imaging revealed a pancreatic tail mass with hepatic and peritoneal metastases. Laparoscopic biopsy of peritoneal nodules confirmed moderately differentiated adenocarcinoma, and immunohistochemical findings supported pancreatic ductal origin. A final diagnosis of metastatic PDAC was established. Conclusion: Apparent endoscopic healing of multifocal gastroduodenal ulcers does not exclude an underlying systemic malignancy. When the cause of extensive ulcerative disease remains unresolved, especially in the setting of persistent symptoms and dynamic CA19-9 elevation, timely pancreatic imaging should be considered to avoid delayed diagnosis of PDAC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.