A Preliminary Study on Evaluating Reparative Regeneration Potential of Human Amniotic Fluid Stem Cells Spheres in Stress Urinary Incontinence Rats.

Shing-Hwa Lu, Shiaw-Min Hwang, Navneet Kumar Dubey, Ming-Song Tsai, Tien-Fu Yun, Jiunn-Wang Liao

Abstract read

In one paragraph

Article in International journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shing-Hwa LuDepartment of Urology, Taipei Medical University Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-2439-0130

Shiaw-Min HwangU-Neuron Biomedical Inc., New Taipei City, Taiwan.ORCID https://orcid.org/0009-0004-9085-9675

Navneet Kumar DubeyDepartment of Biotechnology and Chemical Engineering, School of Engineering, Faculty of Science, Technology and Architecture, Manipal University Jaipur, Dehmi Kalan, India.ORCID https://orcid.org/0000-0002-3540-5281

Ming-Song TsaiSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0001-9732-3698

Tien-Fu YunDepartment of Urology, Taipei Medical University Hospital, Taipei, Taiwan.ORCID https://orcid.org/0009-0000-4217-3530

Jiunn-Wang LiaoGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung, Taiwan.ORCID https://orcid.org/0000-0001-7374-1203

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent reports indicate that stem cell spheres might offer enhanced therapeutic benefits by promoting cell engraftment ability, stemness, angiogenesis, and chemotaxis. Hence, we investigated whether amniotic fluid stem cells (AFSC) spheres could provide therapeutic benefits in stress urinary incontinence (SUI) due to their urethral sphincter-specific commitment. The isolated human AFSCs were characterized by flow-cytometry-based immunophenotyping and their multidifferentiation potential (osteo-, adipo-, and chondrogenic lineages). Time-dependent (>12, 16∼20, and 48 hours) culture conditions for AFSCsphere formation were optimized. Urodynamic parameters, including leak point pressure (LPP) and intercontraction interval (ICI), were determined. hAFSCsphere with ∼150

Indexed as

AFSCsphereAmniotic fluid stem cellsIntercontraction intervalLeak point pressureStress urinary incontinence

Identifiers

PMID42422938

DOI10.15283/ijsc25121

PMCPMC13519539

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.