Evidence map›Paper›PMID 42422944›Full record

ArticleCirculation research2026

AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin.

Qianyun Ge, Kusumika Saha, Micah L Burch, Willow H Battista, Ashmita Kc, Max Homilius, Rachelle A Victorio, Dajun Quan, Hsiang-Ling Huang, Joseph M Hazel and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Qianyun GeDepartment of Molecular Medicine and Therapeutics (Q.G., W.Z.), The Ohio State University, College of Medicine, Columbus.
Kusumika SahaDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).ORCID 0000-0003-4281-6852
Micah L BurchDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).
Willow H BattistaDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).
Ashmita KcDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).
Max HomiliusDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).ORCID 0000-0001-7240-0028
Rachelle A VictorioDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).ORCID 0000-0003-3575-1376
Dajun QuanDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).ORCID 0009-0001-4381-232X
Hsiang-Ling HuangDepartment of Physiology and Cell Biology (H.-L.H., J.M.H., K.C., S.M.H.), The Ohio State University, College of Medicine, Columbus.ORCID 0000-0002-5944-1252
Joseph M HazelDepartment of Physiology and Cell Biology (H.-L.H., J.M.H., K.C., S.M.H.), The Ohio State University, College of Medicine, Columbus.
Alex WilliamsDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).
Emily PanDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).
Krishna ChinthalapudiDepartment of Physiology and Cell Biology (H.-L.H., J.M.H., K.C., S.M.H.), The Ohio State University, College of Medicine, Columbus.ORCID 0000-0003-3669-561X
Sarah M HeisslerDepartment of Physiology and Cell Biology (H.-L.H., J.M.H., K.C., S.M.H.), The Ohio State University, College of Medicine, Columbus.ORCID 0000-0002-6972-7940
Calum A MacRaeDepartment of Medicine, Brigham and Women's Hospital, Boston, MA (K.S., M.L.B., W.H.B., A.K.C., M.H., R.A.V., D.Q., A.W., E.P., C.A.M.).ORCID 0000-0001-5181-2664
Wandi ZhuDepartment of Molecular Medicine and Therapeutics (Q.G., W.Z.), The Ohio State University, College of Medicine, Columbus.ORCID 0000-0003-0927-5687

Funding

Systematically mapping variant effects for cardiovascular genesR01HL164675 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ASHLEY, EUAN A, RODEN, DAN M · 2022 to 2025
$8.1M
A community resource for germline and somatic genetic disease modeling in zebrafishR24OD035402 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI Wolfram Goessling, Calum A. MacRae · 2023 to 2026
$3.5M
Biological basis of cardiac thick filament regulationR01HL181868 · NHLBI · OHIO STATE UNIVERSITY · PI KRISHNA CHINTHALAPUDI, Julian Stelzer · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL164675NHLBI NIH HHS R01 HL181868NIH HHS R24 OD035402
6 · The paper itself

Abstract

backgroundVariants in

methodsWe generated transgenic zebrafish expressing wild-type or pathogenic variant

resultsTg

conclusionsThe

Indexed as

AMP-Activated Protein KinasesArrhythmias, CardiacCardiomegalyZebrafish ProteinsAction PotentialsAnimalsAnimals, Genetically ModifiedGlycogenHumansMyocardial ContractionMyocytes, CardiacPhosphorylationZebrafishAMP-Activated Protein KinasesGlycogenPRKAG2 protein, humanZebrafish Proteinsarrhythmias, cardiaccardiomyopathy, hypertrophicelectrophysiologyglycogenhypertrophymyocytes, cardiacmyosins

Identifiers

PMID42422944
PMCPMC13475725

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.