ArticleHuman cell2026
PD-1/PD-L1 inhibitor induces systemic inflammation and alters cardiac lipid metabolism in C57BL/6 J mice.
Article in Human cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
Abstract
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, and their side effects, such as cardiotoxicity, have become critical complications. Herein, we explored the potential mechanism of ICIs-related cardiotoxicity. Healthy male C57BL/6 J mice were intraperitoneally injected with a PD-1/PD-L1 inhibitor (BMS-1) at a total dose of 60 mg/kg. BMS-1 treatment led to cardiac injury, with elevated cardiac enzyme levels, numbers of apoptotic cells, cardiomyocyte cross-sectional areas, and α-SMA expression. BMS-1-induced H9c2 cardiomyocyte injury was immune cell dependent. Compared with the control treatment, BMS-1 treatment did not significantly alter the T-cell composition in the peripheral blood or spleen. However, fluorescence imaging revealed increased numbers of CD3
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Registered trials
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