Evidence map›Paper›PMID 42423924›Full record

ArticleMolecular diversity2026

Design, synthesis, and anti-prostate cancer activity evaluation of novel thieno[2,3-b]pyridine derivatives as potential BLM helicase inhibitors.

Wei Tu, Ningning Zan, Xinyu Liu, Gang Yu, Xiaoping Zeng, Yafang Zhou, Jia Yu, Xueling Meng, Kun Liu, Xiaolin Peng and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei Tu *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Ningning Zan *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Xinyu LiuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Gang YuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Xiaoping ZengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Yafang ZhouState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Jia YuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Xueling MengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Kun LiuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Xiaolin PengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Sha ChengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. chengsha@gmc.edu.cn.
Bixue XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. bixue_xu@126.com.
Guangcan XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. xgc0707@163.com.ORCID https://orcid.org/0000-0001-8991-1916

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, twenty-four novel thieno[2,3-b]pyridine derivatives were rationally designed and synthesized based on a versatile key intermediate. All compounds were evaluated for in vitro antiproliferative activity against PC3 and VCaP prostate cancer cell lines using the MTT assay, and most exhibited good antitumor potency. Compound 9v showed the strongest activity, with IC

Indexed as

2-Chloro-3-cyanopyridineAnti‑prostate cancerBLM helicaseMolecular dockingThieno[2,3-b]pyridine derivatives

Identifiers

PMID42423924

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.