Evidence map›Paper›PMID 42424747›Full record

ArticleThe journal of prevention of Alzheimer's disease2026

MIND GamePack: A novel digital health technology for assessment of participants with and without cognitive impairment.

Jake A Galler, Liuqing Yang, Chao-Yi Wu, Cathrine Young, Edmarie Guzmán-Vélez, Katherine W Cropp, Anthony W Bannon, Hiroko H Dodge, Jessica A Gerber, Steven E Arnold

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In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jake A GallerDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States.
Liuqing YangAbbVie Inc., 1 Waukegan Rd., North Chicago, IL, 60064, United States.
Chao-Yi WuDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States.
Cathrine YoungDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States.
Edmarie Guzmán-VélezDepartment of Neurology, Rutgers Robert Wood Johnson Medical School, 112 Paterson Street, New Brunswick, NJ, 08901, United States.
Katherine W CroppDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States.
Anthony W BannonAbbVie Inc., 1 Waukegan Rd., North Chicago, IL, 60064, United States.
Hiroko H DodgeDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States.
Jessica A GerberDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States.
Steven E ArnoldDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, United States. Electronic address: searnold@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDigital biomarkers offer promising avenues for enhancing the identification, prognosis, and phenotyping of Alzheimer's Disease (AD). This study evaluates the feasibility and utility of the MIND GamePack©, a digital game platform designed to measure leisure cognitive activity over time.

methodsGameplay data were collected from 60 participants across two cohorts over 3-6 months: Cohort I (no cognitive complaints) and Cohort II (subjective complaints, mild cognitive impairment, mild dementia). Analyses focused on compliance, correlation with validated neuropsychological instruments (Montreal Cognitive Assessment [MoCA], Repeatable Battery for the Assessment of Neuropsychological Status [RBANS], and Trail Making Test [TMT]), test-retest reliability, and known groups comparison.

resultsThe MIND GamePack© displayed high compliance and excellent test-retest reliability within 1 week (ICC=0.81-0.95) for most selected features. Several game features displayed moderate to strong correlations with standardized neuropsychological test performance. Features related to memory tasks across select games (Normalized Accuracy and Normalized Redundant Move Variability of Memory Match and Word Repetition Rate of Word Scramble) exhibited significant associations with RBANS Sum of Index Score, TMT Part A, and MoCA, respectively. Participants without cognitive impairment exhibited improvement in features over 3 months compared to those with cognitive impairment. Baseline game features differentiated cognitively normal [CN] from cognitively impaired [CI] participants across nearly all domains after controlling for age, sex, and education (p<.01).

conclusionsThe MIND GamePack© offers a sensitive, engaging approach to cognitive monitoring and screening, with potential use for dense tracking in longitudinal research and interventional clinical trials.

Indexed as

Alzheimer DiseaseCognitive DysfunctionVideo GamesAgedAged, 80 and overDigital HealthDigital MediaFemaleHumansMaleNeuropsychological TestsReproducibility of ResultsDigital biomarkersDigital health technologiesHigh-frequency samplingNeuropsychological testingRemote cognitive assessment

Identifiers

PMID42424747
PMCPMC13380716

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.