ArticleJACC. Advances2026
Electrical and Structural Atrial Remodeling Identifies a High-Risk Phenotype in Embolic Stroke of Undetermined Source.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEmbolic stroke of undetermined source (ESUS) carries a substantial recurrence risk, yet anticoagulation has not proven superior to antiplatelet therapy in unselected patients. Atrial cardiomyopathy, reflecting electrical and structural atrial remodeling, may identify a high-risk ESUS subgroup.
objectivesThe purpose of this study was to characterize the extent of electrical and structural atrial remodeling in patients with ESUS and to evaluate its association with adverse cardiovascular outcomes during follow-up.
methodsIn this prospective single-center study, 103 consecutive ESUS patients and 123 age- and sex-matched controls without known cardiac disease underwent clinical evaluation, NT-proBNP measurement, 12-lead electrocardiogram, and transthoracic echocardiography. Patients were followed for ≥12 months. The primary endpoint was a composite of all-cause death, recurrent stroke, transient ischemic attack, myocardial infarction, or newly diagnosed atrial fibrillation. Independent predictors were determined using multivariable Cox regression.
resultsESUS patients exhibited higher NT-proBNP, more frequent advanced interatrial block, and impaired left atrial function compared with controls. Over a median follow-up of 382 days (IQR: 366-697 days), 29 ESUS patients (29/103, 28%) reached the primary endpoint. Independent predictors were NT-proBNP >420 pg/mL, advanced interatrial block, E' ≤9 cm/s, left atrial volume index ≥29 mL/m
conclusionsMultimodal assessment of electrical and structural atrial remodeling identifies a subgroup of ESUS patients with an increased risk of adverse events. These findings underscore the potential clinical relevance of atrial cardiomyopathy and may support further evaluation in future rhythm-guided or anticoagulation studies.
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