Evidence map›Paper›PMID 42425519›Full record

ArticleBritish journal of haematology2026

Physiologically based serum hepcidin and ferritin thresholds identify similar onsets of iron-deficient erythropoiesis in adult blood donors.

O Yaw Addo, Gary M Brittenham, Zuguo Mei, Maria Elena D Jefferds, Rafael C Flores-Ayala, Daysha Fliginger, Joseph Lipschitz, Annie Qiu, Steven L Spitalnik, Eldad A Hod

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

O Yaw AddoNutrition Branch, Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Gary M BrittenhamDepartment of Pediatrics, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Zuguo MeiNutrition Branch, Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Maria Elena D JefferdsNutrition Branch, Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Rafael C Flores-AyalaNutrition Branch, Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Daysha FligingerDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Joseph LipschitzDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Annie QiuDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Steven L SpitalnikDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Eldad A HodDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Red blood cells from iron-deficient donors: recovery and storage qualityR01HL133049 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOD, ELDAD ARIE, SPITALNIK, STEVEN L · 2016 to 2020
$3.8M
Neurocognitive effects of iron deficiency in blood donors.R01HL139489 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOD, ELDAD ARIE · 2018 to 2021
$2.4M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1TR001873NHLBI NIH HHS HL133049NHLBI NIH HHS HL139489NHLBI NIH HHS R01 HL133049NHLBI NIH HHS R01 HL139489
6 · The paper itself

Abstract

To compare physiologically based serum hepcidin and ferritin thresholds for iron deficiency in adult female and male blood donors, we analysed laboratory results obtained during screening for a blood donor study. In 907 apparently healthy blood donors, we examined the relationships of hepcidin and ferritin with five indicators of the onset of iron-deficient red blood cell production: haemoglobin (Hb), soluble transferrin receptor (sTfR), erythrocyte zinc protoporphyrin (ZPP), reticulocyte haemoglobin content (Retic-Hb) and mean corpuscular volume (MCV). Serum hepcidin and ferritin were correlated (Pearson's r = 0.69, p = <0.001 females; r = 0.65, p < 0.001, males). At lower serum hepcidin and ferritin concentrations, Hb, Retic-Hb and MCV decreased and sTfR and ZPP increased. Using restricted cubic spline models, the hepcidin thresholds for iron deficiency in adult female donors 18-49 years, 50-75 years and all male blood donors 18-75 years old were 13.9, 24.8 and 28.8 μg/L respectively. The corresponding ferritin thresholds were 25.4, 30.7 and 32.5 μg/L respectively. Among blood donors 18-50 years old, serum hepcidin and ferritin thresholds for iron deficiency were lower in women than in men but were similar after 50 years of age. In conclusion, among adult blood donors, serum hepcidin and ferritin thresholds are similarly effective for detecting iron deficiency, especially among women.

Indexed as

Anemia, Iron-DeficiencyBlood DonorsErythropoiesisFerritinsHepcidinsIron DeficienciesAdolescentAdultAgedBiomarkersBlood DonationErythrocyte IndicesFemaleHemoglobinsHumansMaleBiomarkersFerritinsHemoglobinsHepcidinsProtoporphyrinszinc protoporphyrinanaemiablood donoriron deficiency

Identifiers

PMID42425519
PMCPMC13462215

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.