Evidence map›Paper›PMID 42425929›Full record

ArticleJournal of agricultural and food chemistry2026

Prenatal Choline and Betaine Differentially Program Adult Hepatic One-Carbon Metabolism in Wistar Rats.

Gia V Shelp, Justin Tang, Jianzhang Dong, Mali Al-Issa, Nisa Butt, Elizabeth M Poole, Sarah E Burns, Emanuela Pannia, Marica Bakovic, Clara E Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gia V ShelpDepartment of Human Health Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Justin TangDepartment of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Jianzhang DongDepartment of Human Health Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Mali Al-IssaDepartment of Human Health Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Nisa ButtDepartment of Human Health Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Elizabeth M PooleDepartment of Family Relations and Applied Nutrition, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Sarah E BurnsDepartment of Family Relations and Applied Nutrition, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Emanuela PanniaDepartment of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada.
Marica BakovicDepartment of Human Health Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Clara E ChoDepartment of Human Health Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.ORCID 0000-0002-9733-2516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Choline, an essential methyl donor nutrient, and its oxidation product betaine support one-carbon metabolism in early development, yet their prenatal effects on offspring hepatic metabolites and methyltransferase expression remain unknown. Gestational choline or betaine supplementation lowered Wistar rat offspring body weight, food intake, and relative adipose mass compared to the control. Both nutrients increased hepatic glycerophosphocholine in females and males, while betaine elevated sphingomyelin in males and dimethylglycine in both sexes. Choline and betaine raised hepatic

Indexed as

BetaineCarbonCholineLiverAnimalsDNA (Cytosine-5-)-Methyltransferase 1FemaleMalePhosphatidylethanolamine N-MethyltransferasePregnancyRatsRats, WistarS-AdenosylmethionineBetaineCarbonCholineDNA (Cytosine-5-)-Methyltransferase 1Phosphatidylethanolamine N-MethyltransferaseS-Adenosylmethioninebetainecholinemetabolitesmethylationmethyltransferasesone-carbon metabolism

Identifiers

PMID42425929
PMCPMC13398504

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.