A novel electrochemical sensor based on Al-doped ZnO nanoparticles-modified carbon paste electrode for ivabradine sensitive monitoring in human plasma.

Mona A Kamel, Amr M Mahmoud, Christine K Nessim, Adel M Michael, Samah S Abbas, Hoda M Marzouk

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Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Mona A KamelPostgraduate Program in Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Amr M MahmoudPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Christine K NessimChemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, 12566, Cairo, Egypt.

Adel M MichaelChemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, 12566, Cairo, Egypt.

Samah S AbbasPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Hoda M MarzoukPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. hodaallah.marzouk@pharma.cu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sustainable, fast, sensitive, and selective electrochemical determination of ivabradine (IVB) is vital for pharmaceutical assessment and clinical monitoring. IVB is a selective heart rate-reducing medication that plays an important role in improving symptoms and decreasing hospitalizations for patients with chronic heart failure, particularly when beta-blockers are not appropriate. Recent studies have explored improving electrode performance through nanomaterial-based modifications, such as metal oxides and carbon nanocomposites. Currently, there are no reports on using Al-doped ZnO (AZO) nanoparticles-modified carbon paste electrodes (CPE) for IVB analysis. The prepared nanoparticles were thoroughly characterized utilizing Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy-dispersive X-ray analysis (EDX). The electrochemical properties of IVB at AZO/CPE were examined via differential pulse voltammetry (DPV) in Britton-Robinson buffer (pH 2.0). Among the investigated bare and ZnO-based modified CPEs (Mn-, Ni-, and Al-doped), AZO/CPE demonstrated the highest anodic oxidation response toward IVB, confirming its enhanced electrocatalytic performance. The influence of scan rate on IVB electrochemical oxidation was examined with AZO/CPE cyclic voltammetry (CV). Under optimized experimental conditions, the peak current of IVB showed a linear relationship with its concentration from 5.0 × 10

Indexed as

AluminumCarbonElectrochemical TechniquesIvabradineMetal NanoparticlesNanoparticlesZinc OxideElectrodesHumansLimit of DetectionAluminumCarbonIvabradineZinc OxideAl-doped ZnO nanoparticlesBiological samplesCarbon paste electrodeDifferential pulse voltammetryIvabradineSustainability

Identifiers

PMID42426210

DOI10.1016/j.bios.2026.118890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.