Evidence map›Paper›PMID 42426211›Full record

ArticleMolecular psychiatry2026

The role of the globus pallidus subregions in the schizophrenia spectrum continuum.

Naohiro Okada, Kentaro Morita, Shimon Tonsho, Masahiro Kiyota, Eimu Shoji, Daisuke Koshiyama, Shinsuke Koike, Syudo Yamasaki, Atsushi Nishida, Shuntaro Ando and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Naohiro OkadaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan. nokada-tky@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-8338-2758
Kentaro MoritaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Shimon TonshoDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Masahiro KiyotaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Eimu ShojiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0009-0005-1554-3387
Daisuke KoshiyamaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0003-2744-0981
Shinsuke KoikeInternational Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID http://orcid.org/0000-0002-3375-236X
Syudo YamasakiResearch Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa 2-1-6, Setagaya-ku, Tokyo, 156-8506, Japan.ORCID http://orcid.org/0000-0002-9016-6404
Atsushi NishidaResearch Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa 2-1-6, Setagaya-ku, Tokyo, 156-8506, Japan.ORCID http://orcid.org/0000-0001-6451-7699
Shuntaro AndoDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0003-1595-693X
Noriaki YahataDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Kouhei KamiyaDepartment of Radiology, Toho University Omori Medical Center, Omori-nishi 6-11-1, Ota-ku, Tokyo, 143-8541, Japan.
Akira KunimatsuDepartment of Radiology, International University of Health and Welfare Mita Hospital, Mita 1-4-3, Minato-ku, Tokyo, 108-8329, Japan.
Osamu AbeDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0002-1180-2629
Sho YagishitaInternational Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID http://orcid.org/0000-0003-2854-773X
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0002-4443-4535

Funding

Japan Agency for Medical Research and Development (AMED) JP19dm0207069Japan Agency for Medical Research and Development (AMED) JP19dm0207069, JP19dm0307001, JP19dm0307004, JP23wm0625001MEXT | Japan Science and Technology Agency (JST) JPMJMS2021MEXT | Japan Society for the Promotion of Science (JSPS) JP16H06395, JP16H06399, JP16K21720, JP16H06280, JP17H04244, JP21H05171, JP21H05174MEXT | Japan Society for the Promotion of Science (JSPS) JP16H06398, JP20H01777MEXT | Japan Society for the Promotion of Science (JSPS) JP16H06398, JP20H03951, JP21H05173, JP21K10487, JP23H05472, JP24H00666MEXT | Japan Society for the Promotion of Science (JSPS) JP18K15478, JP22H04926, JP22K18419, JP25K10853MEXT | JST | Research Institute of Science and Technology for Society (RISTEX) JPMJRS24K1
6 · The paper itself

Abstract

Within the cortico-basal ganglia network, the volume and functional connectivity (FC) of the globus pallidus (GP) are altered in schizophrenia-spectrum disorders, with GP enlargement being relatively specific to schizophrenia compared to other disorders. However, little is known about alterations in its two major segments, externus (GPe) and internus (GPi), in schizophrenia-spectrum disorders. In this study, we compared GPe/GPi volume and FC between patients with schizophrenia and controls (n > 100), and examined the associations of GPe/GPi volume and FC with subclinical psychotic experiences (SPEs) in early adolescents (n > 200). We found GPe-dominant enlargement and GP subregion-specific FC patterns (e.g., increased left GPe FC with the lateral occipitoparietal area and decreased left GPi FC with the precuneus) in schizophrenia. Additionally, we observed a positive association between GPe volume and SPEs in adolescence, as well as GP subregion-specific FC patterns (e.g., larger left GPe FC with the lingual gyrus) in adolescents with SPEs compared to those without. Future translational studies are needed to elucidate the mechanisms underlying such GP subregion-specific neurophysiological roles.

Identifiers

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.