ReviewExpert reviews in molecular medicine2026
Convergent Microenvironment Linking Idiopathic Pulmonary Fibrosis and Lung Cancer.
Review in Expert reviews in molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundIdiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with limited treatment options and a poor prognosis. Lung cancer (LC) is one of the most common comorbidities in IPF, and IPF is recognized as an independent risk factor for the development of LC. In recent years, increasing evidence has suggested that these two diseases may share convergent genetic, epigenetic and cellular mechanisms, particularly within their microenvironments.
methodsA comprehensive literature search was performed across PubMed, Web of Science, and Google Scholar databases to identify relevant studies focusing on the shared cellular components, immune and stromal behaviors, and pathogenic pathways within the microenvironments of IPF and LC.
resultsThis review delineates the convergent features of the IPF and LC microenvironments by synthesizing the functional reprogramming of key cellular constituents. The immunological landscape is characterized by aberrant macrophage polarization, T-cell exhaustion and the accumulation of immunosuppressive myeloid-derived suppressor cells and immature dendritic cells. Furthermore, profound stromal alterations are observed, encompassing fibroblast activation, pathological extracellular matrix remodelling, epithelial-mesenchymal transition and dysregulated angiogenesis. These common cellular and molecular alterations may simultaneously drive fibrosis progression and tumorigenesis.
conclusionsA deeper understanding of the relationship between the IPF and LC microenvironments will help identify shared pathological mechanisms and provide new insights for developing more targeted diagnostic and therapeutic strategies for idiopathic pulmonary fibrosis associated with lung cancer (IPF-LC).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.