ArticleThe Journal of international medical research2026
Association of high-sensitivity C-reactive protein-to-hemoglobin ratio with stroke risk: A study based on the China Health and Retirement Longitudinal Study and English Longitudinal Study of Ageing cohorts.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveTo investigate the association between the high-sensitivity C-reactive protein-to-hemoglobin ratio and stroke risk among middle-aged and older adults.MethodsA prospective follow-up study was conducted using cohort data from the China Health and Retirement Longitudinal Study (CHARLS) and the English Longitudinal Study of Ageing (ELSA). Participants without a history of stroke at baseline were included, comprising 5368 individuals from CHARLS and 1422 from ELSA. Cox proportional hazards regression models were used to analyze the association between C-reactive protein-to-hemoglobin ratio levels and stroke risk, along with dose-response analyses and subgroup interaction testing.ResultsAfter adjusting for sex, age, lifestyle factors, and multiple clinical biochemical indicators, the participants in Q2, Q3, and Q4 demonstrated a significantly higher risk of stroke than those in Q1 (reference group). The hazard ratios were 2.23 (1.35-3.69), 2.24 (1.36-3.71), and 3.14 (1.93-5.12), respectively (all
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