Trial reportBMC gastroenterology2026
Potential benefit of mirabilite external dressing combined with abdominal drainage in the early stage of severe acute pancreatitis.
Trial report in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
aimTo evaluate the potential benefit of external mirabilite dressing combined with abdominal drainage for treating severe acute pancreatitis (SAP).
methodsThis retrospective study included SAP patients from two centres who were divided into three groups: combined therapy (A, n = 24), mirabilite alone (B, n = 31), and drainage alone (C, n = 25). The outcomes included symptom recovery, laboratory parameters, intra-abdominal pressure (IAP), imaging findings, complications, and costs. Quantile regression adjusted for the Ranson score was performed.
resultsDespite the higher baseline Ranson score in Group A (4.00 vs. 3.00 in B and 4.00 in C; p = 0.026), Group A had a faster time to abdominal pain relief (7.50 vs. 11.00 and 9.00 days; P = 0.016), a faster time to flatus (2.00 vs. 3.00 and 2.00 days; P = 0.042), and faster white blood cell count normalization (3.00 vs. 6.00 and 5.00 days; P = 0.049). The IAP at discharge was lowest in Group A (7.35 vs. 8.46 and 8.82 mmHg, P = 0.032). Exudate area reduction (741.06 vs. 164.03 and 494.20 mm², P = 0.001) and pseudocyst area (323.94 vs. 484.30 and 453.38 mm², P = 0.038) were also both better in Group A. No differences were observed in the incidence of complications or health economic indicators (all p > 0.05).
conclusionIn this retrospective, non-randomized study, combining external mirabilite dressing with abdominal drainage in early-stage SAP patients was associated with short-term clinical benefits without increasing total hospitalization costs. These findings are hypothesis-generating and require prospective validation.
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