Evidence map›Paper›PMID 42426688›Full record

ArticleBMC cancer2026

Detection of thyroglobulin, TSH receptor and sodium-iodine symporter mRNA for identification of lymph node metastases in patients with papillary thyroid carcer.

Lei Gao, Yu Bao, Tie-Xin Li, Guo-Qing Liu, Fu-Xing Zhang, Ying-Chao Chen, Bing Han, Lu Li, Huai-Dong Song, Mu-Lin Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lei Gao *Bengbu Medical University, Bengbu Anhui, 233030, China.
Yu Bao *Bengbu Medical University, Bengbu Anhui, 233030, China.
Tie-Xin LiBengbu Medical University, Bengbu Anhui, 233030, China.
Guo-Qing LiuBengbu Medical University, Bengbu Anhui, 233030, China.
Fu-Xing ZhangBengbu Medical University, Bengbu Anhui, 233030, China.
Ying-Chao ChenInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Bing HanInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Lu LiDepartment of Endocrinology and Metabolism, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Huai-Dong Song *Department of Molecular Diagnostics & Endocrinology, The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. huaidong_s1966@163.com.
Mu-Lin Liu *Department of General Surgery, The Central Laboratory of the First Affiliated Hospital of Bengbu Medical University, Bengbu Anhui, 233000, China. liumulin66@aliyun.com.
Mei Dong *Department of Molecular Diagnostics & Endocrinology, The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. dm20180301@163.com.

Funding

National Natural Science Foundation of China 82103788National Natural Science Foundation of China 82270826
6 · The paper itself

Abstract

backgroundPapillary thyroid carcer (PTC) is the most prevalent endocrine malignancy, with the morbidity increase in recent years. The presence of metastatic lymph nodes stands as a significant predictor for recurrent occurrences of the disease. In this study, we explored the utility of biomarkers in aiding the identification of lymph node metastases in patients with PTC.

methodsWe gathered 388 formalin-fixed paraffin embedded (FFPE) lymph node specimens from 266 individuals who had undergone surgical procedures for PTC. These samples were analyzed for the mRNA expression level of thyroglobulin (TG), TSH receptor (TSHR), and sodium-iodide symporter (NIS) using the real-time fluorescence quantitative PCR (qPCR) method. The results were compared with pathologic diagnosis.

resultsAmong 134 confirmed lymph node metastasis tissues, it was found that 123 samples expressed TG mRNA, 118 samples expressed TSHR mRNA and only 16 samples expressed NIS mRNA. Among 254 nonmetastatic lymph node tissues, 240 samples did not express TG mRNA, 219 samples did not express TSHR mRNA and 230 samples did not express NIS mRNA. The findings suggest that the measure of TG mRNA for the diagnosis of lymph node metastasis has a 91.79% sensitivity rate and a 94.49% specificity rate. The detection of TSHR mRNA displays an 88.06% sensitivity and an 86.22% specificity for recognizing lymph node metastasis. However, mRNA expression of NIS was not detected in most of lymph node samples.

conclusionsThe research suggests that identifying TG mRNA expression in lymph nodes could serve as an effective approach to aid in postoperative diagnosing lymph node metastasis in patients with PTC.

Indexed as

Biomarkers, TumorReceptors, ThyrotropinSymportersThyroglobulinThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedFemaleHumansLymphatic MetastasisLymph NodesMaleMiddle AgedRNA, MessengerSodium-Iodide SymportersBiomarkers, TumorReceptors, ThyrotropinRNA, MessengerSodium-Iodide SymportersSymportersThyroglobulinTSHR protein, humanLymph node metastasesmRNA expressionPapillary thyroid cancerqPCRSodium-iodide symporterThyroglobulinTSH receptor

Identifiers

PMID42426688
PMCPMC13637262

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.