ArticleJournal of medicinal chemistry2026
Discovery of Novel Synthetic Cyclohexene-Based Small Molecules Targeting Senescence against Age-Related Pulmonary Fibrosis.
Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Targeting cellular senescence has emerged as a therapeutic strategy for the increasingly prevalent age-related diseases, yet no drugs have reached clinical approval specifically as senotherapeutics. Through senescence-phenotype screening of our recently generated human microbiota-inspired library of small molecules, we identified a tetrasubstituted cyclohexene as a novel bioactive chemotype. Following the synthesis of related analogues and their evaluation in relevant models of senescence, we discovered compound
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