ArticleJournal of mass spectrometry : JMS2026
Evaluation of Surface Acoustic Wave Nebulization for NEMS Mass Spectrometry.
Article in Journal of mass spectrometry : JMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Nano-electromechanical systems mass spectrometry (NEMS-MS) enables single-particle mass measurements with resolving power that increases for ultra-massive analytes, but its practical sensitivity is currently limited by sample introduction methods. Here, we evaluated surface acoustic wave nebulization (SAWN) as a suitable particle source for NEMS-MS. A compact SAW-based nebulizer was characterized using scanning mobility particle sizer (SMPS) measurements of sucrose residues, yielding a mean droplet diameter of ~2.0 μm and a transmission efficiency of up to 30%. Nebulization of solid nanoparticles was validated using polystyrene latex (PSL) standards. Application of SAWN-NEMS-MS to biological capsid-like particles (CLP) revealed substantial nonvolatile salt adduction, contributing to the detected mass and broadening mass distributions. At high particle concentrations, multiparticle encapsulation produced aggregates exceeding 100 MDa. Our findings outline the potential and limitations of SAWN for single-particle NEMS-MS: while demonstrating enhanced transfer efficiency, our results indicate that reduced droplet sizes and extensive desalting are essential requisites for achieving native analysis of large biological assemblies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.