ArticleAdvanced biomedical research2026
The Impact of Combined Vitamin D and A Supplementation on Clinical Outcomes in Patients with Pneumosepsis: A Randomized Double-Blind Clinical Trial.
Article in Advanced biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pneumosepsis is a severe and potentially life-threatening infection of the lower respiratory tract. This study aimed to investigate the effect of combined vitamin D and A supplementation on clinical outcomes in patients with pneumosepsis. Material and Methods: Eighty-four patients with pneumosepsis were randomly assigned to four groups in this double-blind clinical trial. Group 1 received standard treatment plus 300,000 IU intramuscular vitamin D and 50,000 IU intramuscular vitamin A. Group 2 received standard treatment plus 300,000 IU intramuscular vitamin D. Group 3 received standard treatment plus 50,000 IU intramuscular vitamin A. Group 4 received standard treatment only. Clinical parameters including ESR, CRP, creatinine, urea, and uric acid levels were recorded at baseline, 24, 48, and 72 hours after intervention. Results: The combined vitamin D and A group (Group 1) demonstrated significantly lower blood pressure, respiratory rate, heart rate, temperature, ESR, CRP, and white blood cell count compared to the other groups at all three time points. Conclusion: The study suggests that combined vitamin D and A supplementation, in addition to standard treatment, may improve clinical outcomes and potentially reduce the duration of hospitalization in patients with pneumosepsis. However, further research is warranted to confirm these findings and elucidate the underlying mechanisms. Trial Registration: This study is registered on Iranian Registry of Clinical Trials (IRCT) under the identifier IRCT20130424013110N10. (The registration date: July 6, 2020).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.