ArticlebioRxiv : the preprint server for biology2026
Hydrophobic mismatch induces lipid sorting based on tail unsaturation.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biological membranes contain a diverse set of membrane proteins surrounded by many different lipids, and the lateral organization and function of these molecules are closely intertwined. Here, we use coarse-grained molecular dynamics (MD) simulations to explore how hydrophobic mismatch between the length of transmembrane (TM) proteins and the thickness of the surrounding lipid membrane impacts the spatial distribution of the lipids. We constructed idealized cylindrically symmetric proteins, inspired by the "Mattress Model" developed in the 1980's, and simulated these model proteins in different lipid compositions. We found that unsaturated lipids were attracted to
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