Evidence map›Paper›PMID 42427504›Full record

ArticlebioRxiv : the preprint server for biology2026

Cardiovascular Benefits of Menopause Hormone Treatment is Age-Dependent.

Cassandra D Lalisan, Connor Gavin, Bridget Litts, Jeffrey A Rein, Julia An, Min Zhong, Rajguru Boobalan, Yu Wang, Amelia Van Aelst, Sivaprakasam Chinnarasu and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cassandra D LalisanDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0009-0004-0505-2499
Connor GavinDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Bridget LittsDivision of Diabetes, Metabolism and Endocrinology, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8647-4677
Jeffrey A ReinDivision of Diabetes, Metabolism and Endocrinology, Vanderbilt University Medical Center, Nashville, TN.
Julia AnDivision of Diabetes, Metabolism and Endocrinology, Vanderbilt University Medical Center, Nashville, TN.
Min ZhongDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Rajguru BoobalanDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Yu WangDepartment of Biostatistics, Vanderbilt University, Nashville, TN.
Amelia Van AelstDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Sivaprakasam ChinnarasuDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0009-0002-1863-862X
Yaomin XuDepartment of Biostatistics, Vanderbilt University, Nashville, TN.ORCID 0000-0002-3752-4006
MacRae LintonDivision of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-9277-0453
John M StaffordDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0000-0001-6527-959X
Lin ZhuDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0000-0001-8149-4273

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hormone therapy (HT) has not consistently reduced atherosclerotic cardiovascular disease (ASCVD) events in post-menopausal women, yet the underlying mechanisms remain poorly understood. Methods: Female Results: In aging mice, menopause E Conclusions: The cardiovascular effects of estrogen therapy are fundamentally age dependent. Aging shifts estrogen signaling toward hepatic oxidative stress and inflammation through increased GPER. While E

Identifiers

PMID42427504
PMCPMC13345000

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.