ArticlebioRxiv : the preprint server for biology2026
Small Structural Variations, Large Functional Consequences: Comparative Analysis Reveals Structural Control of Ubiquitylation Site Selection by BRCA1/BARD1.
Sahar Heidari, Caitlin Lightle, Lauren Herrington, Tejas Shah, Fariha Hossain, Faruck Morcos, Susan T Weintraub, Mikaela D Stewart, Hedieh Torabifard
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Sahar HeidariDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080 USA.ORCID 0009-0005-4530-5670 Caitlin LightleBiology Department, Texas Christian University, Forth Worth, TX 76129 USA.
Lauren HerringtonBiology Department, Texas Christian University, Forth Worth, TX 76129 USA.
Tejas ShahDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080 USA.
Fariha HossainDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080 USA.
Faruck MorcosDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080 USA.ORCID 0000-0001-6208-1561 Susan T WeintraubDepartment of Biochemistry & Structural Biology, The University of Texas Health San Antonio, San Antonio, TX 78229 USA.
Mikaela D StewartBiology Department, Texas Christian University, Forth Worth, TX 76129 USA.
Hedieh TorabifardDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080 USA.ORCID 0000-0003-0687-6858 Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MComputational Tools to Characterize the Effects of Protein and RNA Variability in Function and InteractionsR35GM133631 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Alonso Faruck Morcos · 2019 to 2026
$3.0MComputational framework to investigate the inorganic ion transportersR35GM155106 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Hedieh Torabifard · 2024 to 2026
$1.2MDisrupting Protein-Protein Interactions with Self-Assembling MacrocyclesR15GM135900 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI SIMANEK, ERIC E, STEWART, MIKAELA · 2019 to 2023
$736kNCI NIH HHS P30 CA054174NIGMS NIH HHS R15 GM135900NIGMS NIH HHS R35 GM133631NIGMS NIH HHS R35 GM155106
6 · The paper itselfAbstract
BRCA1/BARD1 is a chromatin-associated E3 ubiquitin ligase that ubiquitylates histone H2A to coordinate DNA damage repair, transcriptional repression, and genome stability. In
Indexed as
BARD1BRCA1C. elegansH2Anucleosome bindingubiquitylation
Identifiers
PMID42427510
PMCPMC13345330
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390