Evidence map›Paper›PMID 42427556›Full record

ArticlebioRxiv : the preprint server for biology2026

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses.

Marwa Saad, Alexandra Thoms, Yue S Yin, Izabela Mamede, Afsana Rahman, Ruonan Chen, Sebastián E Carrasco, Patrick W Darcy, Norihiro Goto, Sohail F Tavazoie and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marwa SaadLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.
Alexandra ThomsLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.
Yue S YinLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.
Izabela MamedeLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.
Afsana RahmanLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.
Ruonan ChenLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.
Sebastián E CarrascoLaboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Rockefeller University, New York, New York, United States.
Patrick W DarcyLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.
Norihiro GotoThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, United States.
Sohail F TavazoieLaboratory of Systems Cancer Biology, The Rockefeller University, New York, United States.
Angelina M BilateLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.ORCID 0000-0003-4575-786X
Daniel MucidaLaboratory of Mucosal Immunology, The Rockefeller University, New York, United States.ORCID 0000-0002-0000-0452

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer mortality, with most cases refractory to immunotherapy. Distinguishing tumor-induced from steady-state mucosal T cell responses has been a critical barrier to understanding antitumor immunity in CRC. Using orthotopic transplantation of CRC organoids with and without metastatic potential, combined with temporal T cell fate-mapping, we show that non-metastatic tumors elicit early recruitment of CD8αβ

Identifiers

PMID42427556
PMCPMC13344958

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.