Evidence map›Paper›PMID 42427558›Full record

ArticlebioRxiv : the preprint server for biology2026

Mitochondrial STAT3-mediated suppression of apoptosis constrains antimycobacterial immunity.

C J Mabry, A K Coleman, M H Smith, S L Hahn, T M Newbolt, M J Chapman, L W Stranahan, C G Weindel, K L Patrick, R O Watson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C J MabryDepartment of Microbial Pathogenesis and Immunology, Texas A&M Naresh K. Vashisht College of Medicine, Bryan, TX 77807, USA.
A K ColemanDepartment of Microbial Pathogenesis and Immunology, Texas A&M Naresh K. Vashisht College of Medicine, Bryan, TX 77807, USA.
M H SmithDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
S L HahnDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232.
T M NewboltDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
M J ChapmanDepartment of Microbial Pathogenesis and Immunology, Texas A&M Naresh K. Vashisht College of Medicine, Bryan, TX 77807, USA.
L W StranahanDepartment of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences, College Station, TX 77843, USA.
C G WeindelDepartment of Microbial Pathogenesis and Immunology, Texas A&M Naresh K. Vashisht College of Medicine, Bryan, TX 77807, USA.
K L PatrickDepartment of Microbial Pathogenesis and Immunology, Texas A&M Naresh K. Vashisht College of Medicine, Bryan, TX 77807, USA.
R O WatsonDepartment of Microbial Pathogenesis and Immunology, Texas A&M Naresh K. Vashisht College of Medicine, Bryan, TX 77807, USA.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Chemical Biology of Infectious Diseases (CBID) Training ProgramT32AI112541 · NIAID · VANDERBILT UNIVERSITY · PI Eric P Skaar · 2015 to 2026
$4.0M
Mitochondria as crucial regulators of innate immune outcomes during Mycobacterium tuberculosis infectionR01AI155621 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATRICK, KRISTIN LEIGH, WATSON, ROBERT OWEN · 2021 to 2025
$2.9M
TRIM 14 is a master regulator of STAT3 activity during the macrophage innate immune responses to Mycobacterium tuberculosisF31AI176795 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Cory Mabry · 2024 to 2026
$115k
Characterizing the role of cancer-associated U2AF mutations in immune dysregulationF31CA298557 · NCI · VANDERBILT UNIVERSITY · PI Mackenzie Smith · 2025 to 2026
$100k
The Mycobacterium tuberculosis secreted protein Rv1075c hijacks host histone methyltransferases to promote infectionF31AI176652 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI COLEMAN, AJA · 2024 to 2024
$38k
NCI NIH HHS F31 CA298557NCI NIH HHS P30 CA068485NIAID NIH HHS F31 AI176652NIAID NIH HHS F31 AI176795NIAID NIH HHS R01 AI155621NIAID NIH HHS T32 AI112541NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Maintenance of mitochondrial homeostasis is required to balance the host-pathogen interface during

Indexed as

apoptosiscancerCD8+ T cellsinnate immunitymacrophagemitochondriamitochondrial Stat3mPTPMycobacterium tuberculosisTBK1Trim14

Identifiers

PMID42427558
PMCPMC13344979

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.