Evidence map›Paper›PMID 42427574›Full record

ArticlebioRxiv : the preprint server for biology2026

Legacy Effects of Early β-Adrenergic Stimulation Program Adipose Plasticity and Confer Metabolic Resilience in Obesity.

Pablo E Morales, Wenxin Tong, Lavanya Vishvanath, Danielle C Leander, Taylor E Wade, David S Hallaron, Kimberley El, Robert A Hollander, Ashley Truong, Donald Wothe and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Pablo E MoralesDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Wenxin TongDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Lavanya VishvanathDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Danielle C LeanderDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Taylor E WadeDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
David S HallaronDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Kimberley ElDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Robert A HollanderDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Ashley TruongDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Donald WotheDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
George ElmquistDepartment of Internal Medicine, Touchstone Diabetes Center, University of Texas Southwestern Medical Center; Dallas, TX, USA.
Marjori RussoDepartment of Cell Biology and Physiology, Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.
Heather K HamilosDiabetes and Metabolism Research Center, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
Grace E DewyerDiabetes and Metabolism Research Center, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
Clair CreweDepartment of Cell Biology and Physiology, Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.
William L HollandDiabetes and Metabolism Research Center, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
Timothy R KovesDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Deborah M MuoioDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
David A D'AlessioDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Jessica CannavinoDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Jonathan E CampbellDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Mengle ShaoDepartment of Internal Medicine, Touchstone Diabetes Center, University of Texas Southwestern Medical Center; Dallas, TX, USA.
Rana K GuptaDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · 2022 to 2025
$5.6M
NIDDK NIH HHS P30 DK020579
6 · The paper itself

Abstract

Pathologic white adipose tissue (WAT) remodeling, characterized by fibrosis, inflammation, and adipocyte dysfunction, is a hallmark and driver of metabolic disease in obesity

Identifiers

PMID42427574
PMCPMC13344982

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.