Evidence map›Paper›PMID 42427577›Full record

ArticlebioRxiv : the preprint server for biology2026

Progressive loss of independence in neuronal representations predicts cognitive decline.

Drew E G Sheets, Douglas A Ruff, Ramanujan Srinath, Keon S Allen, John H Morrison, Marlene R Cohen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Drew E G SheetsDepartment of Neurobiology and Neuroscience Institute, University of Chicago, IL, USA.ORCID 0000-0003-4198-4619
Douglas A RuffDepartment of Neurobiology and Neuroscience Institute, University of Chicago, IL, USA.ORCID 0000-0001-7228-8822
Ramanujan SrinathDepartment of Neurobiology and Neuroscience Institute, University of Chicago, IL, USA.ORCID 0000-0002-1832-7250
Keon S AllenDepartment of Neurobiology and Neuroscience Institute, University of Chicago, IL, USA.ORCID 0009-0005-0959-5471
John H MorrisonCalifornia National Primate Research Center, University of California Davis, Davis, California, USA.ORCID 0000-0002-8292-0964
Marlene R CohenDepartment of Neurobiology and Neuroscience Institute, University of Chicago, IL, USA.ORCID 0000-0001-8583-4300

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Tau based Monkey model of Alzheimer's Disease; Structure and FunctionR24AG073138 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAXTER, MARK G, KORDOWER, JEFFREY H · 2021 to 2024
$5.2M
Using Neuronal Populations to Probe Perceptual DecisionsR01EY022930 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COHEN, MARLENE ROCHELLE · 2013 to 2022
$3.8M
Topological bridges between circuits, models, and behaviorRF1NS121913 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COHEN, MARLENE ROCHELLE, MORRISON, JOHN H · 2021 to 2022
$3.2M
CRCNS: Heterogeneous effects of cognition on perception: unique leverage on circuit mechanismsR01EY034723 · NEI · UNIVERSITY OF CHICAGO · PI COHEN, MARLENE ROCHELLE, DOIRON, BRENT D. · 2022 to 2024
$1.2M
Neural basis of flexible decisions in naturalistic environmentsK99EY035362 · NEI · UNIVERSITY OF CHICAGO · PI SRINATH, RAMANUJAN · 2023 to 2024
$228k
The neural basis of stereognosis and its application to neuroprostheticsF31NS134290 · NINDS · UNIVERSITY OF CHICAGO · PI Drew Sheets · 2023 to 2026
$147k
NEI NIH HHS K99 EY035362NEI NIH HHS R01 EY022930NEI NIH HHS R01 EY034723NIA NIH HHS R24 AG073138NIH HHS P51 OD011107NINDS NIH HHS F31 NS134290NINDS NIH HHS RF1 NS121913
6 · The paper itself

Abstract

Intelligent behavior depends on the brain's ability to represent multiple features of the environment simultaneously while keeping those representations independent

Identifiers

PMID42427577
PMCPMC13344996

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.