Evidence map›Paper›PMID 42427583›Full record

ArticlebioRxiv : the preprint server for biology2026

Sex-specific associations between astrocytic reactivity and cognitive decline in unimpaired elderly.

Chelsea Reichert Plaska, Tovia Jacobs, Davide Bruno, Sang Han Lee, Bruno P Imbimbo, Ricardo S Osorio, Andréa L Benedet, Nicholas J Ashton, Henrik Zetterberg, Nunzio Pomara

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chelsea Reichert PlaskaGeriatric Psychiatry Division, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.ORCID 0000-0001-9662-6179
Tovia JacobsPenn State College of Medicine, 700 HMC Cres Rd, Hershey, PA 17033, USA.
Davide BrunoSchool of Psychology, Liverpool John Moores University, Tom Reilly building, L3 3AF, Liverpool, UK.ORCID 0000-0003-1943-9905
Sang Han LeeCenter for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Bruno P ImbimboDepartment of Research & Development, Chiesi Farmaceutici, Largo Francesco Belloli 11/a, 43122 Parma, Italy.
Ricardo S OsorioClinical Research Department, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962.
Andréa L BenedetDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, SE- Wallinsgatan 6, 43141 Mölndal, Sweden.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, SE- Wallinsgatan 6, 43141 Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, SE- Wallinsgatan 6, 43141 Mölndal, Sweden.
Nunzio PomaraGeriatric Psychiatry Division, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

introductionAstrocyte reactivity may contribute to increased Alzheimer's disease (AD) risk in women. Although higher plasma glial fibrillary acidic protein (GFAP) levels have been reported in women, few studies have investigated sex-specific relationships with other plasma AD biomarkers and cognition.

methodsParticipants were enrolled in the Memory Education and Research Initiative, a longitudinal community-based cohort, and underwent evaluation including blood biomarker sampling. The Alzheimer's Disease Neuroimaging Initiative (ADNI) was included as a replication cohort.

resultsUnimpaired women exhibited higher plasma GFAP levels than men (N=584). Higher baseline GFAP was associated with worse longitudinal episodic memory, exclusively in women. In addition, both higher baseline and increasing GFAP levels over time were associated with lower longitudinal plasma Aβ42/40 ratio. The key results were replicated in the ADNI cohort. DISCUSSION: These findings suggest that astrocytic reactivity is more pronounced in women and may contribute to sex-specific vulnerability to AD-related pathology and cognitive decline.

Indexed as

AD riskAmyloid-βAstrocytesEpisodic MemoryGFAPGlobal CognitionPlasma BiomarkersSemantic Memory

Identifiers

PMID42427583
PMCPMC13345015

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.