Evidence map›Paper›PMID 42427633›Full record

ArticlebioRxiv : the preprint server for biology2026

Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling.

Kunal Shroff, Molly C O'Brien, Tyler J Smith, Jialing Fang, Kelly S Yu, Sonia I Lombroso, Shengjie Feng, Chao Chen, Gregory A Mohl, Indigo V L Rose and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kunal ShroffInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.
Molly C O'BrienInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.
Tyler J SmithInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.
Jialing FangInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.
Kelly S YuInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.
Sonia I LombrosoInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.
Shengjie FengDepartment of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA.
Chao ChenDepartment of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA.
Gregory A MohlWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Indigo V L RoseInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.
Nidhi R LokeshDepartment of Biochemistry and Biophysics, University of California, San Francisco; San Francisco, CA 94143, USA.
Mark E PownallDepartment of Biochemistry and Biophysics, University of California, San Francisco; San Francisco, CA 94143, USA.
Lily Y JanDepartment of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA.
Martin KampmannInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, US.ORCID 0000-0002-3819-7019

Funding

Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
The TMEM16 Family of Ion Channels and Lipid ScramblasesR35NS122110 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LILY JAN · 2021 to 2026
$3.2M
Molecular and Genetic Studies of TMEM16C Control of Thermoregulation and Neuronal ExcitabilityR01NS108946 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, LILY Y · 2020 to 2021
$706k
Molecular mechanisms of synapse loss in Alzheimer’s diseaseF30AG087550 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kunal Shroff · 2024 to 2026
$138k
NIA NIH HHS F30 AG087550NIGMS NIH HHS T32 GM141323NINDS NIH HHS R01 NS108946NINDS NIH HHS R35 NS122110NINDS NIH HHS T32 NS115706
6 · The paper itself

Abstract

Neuronal synapses are eliminated during brain development and disease through pruning by glial cells. Individual synapses are marked for engulfment by 'eat-me' signals, which include externalized phosphatidylserine. In apoptotic cells, phosphatidylserine externalization is driven by caspase-dependent activation of Xkr scramblases

Identifiers

PMID42427633
PMCPMC13344984

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.