ArticlebioRxiv : the preprint server for biology2026
Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling.
Asha Kumari, Mohamed Halaby Elbahoty, Resha Rajkarnikar, Khushi Sureja, Manan Virendra Nayyar, Mehri Monavarian, Liz Macias Quintero, Katherine Fuh, Daniel J Tyrrell, Lalita A Shevde and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
13 authors.
Asha KumariDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0002-2508-9879 Mohamed Halaby ElbahotyDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0001-8766-4616 Resha RajkarnikarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0002-8724-0052 Khushi SurejaDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.
Manan Virendra NayyarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.
Mehri MonavarianDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0002-3320-2974 Liz Macias QuinteroDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0001-7641-4582 Katherine FuhDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-7693-2694 Daniel J TyrrellDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0002-0811-6724 Lalita A ShevdeDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0002-1520-1476 Sudarshan AnandDepartment of Cell, Development and Cancer Biology, Department of Radiation Medicine and Knight Cancer Institute, Oregon Health & Science University, Portland, OR.ORCID 0000-0002-4969-6884 Camilla MargaroliDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0003-3952-0778 Karthikeyan MythreyeDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0001-5478-0098 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Ovarian cancer incidence and mortality increase with age, yet how aging shapes tumor progression and the immune microenvironment remains poorly defined. Using orthotopic syngeneic models of distinct cellular origins (ovarian surface epithelial and fallopian tube-derived) in young versus aged mice, we show that aged hosts exhibit higher tumor burden, metastasis and ascites. Follicle depletion in young mice did not recapitulate these effects, indicating contributions beyond hormonal decline. Spatial transcriptomics revealed distinct age dependent intratumoral heterogeneity, with Hedgehog signaling enrichment in CD45
Indexed as
AgingHedgehogImmunosuppressionOvarian cancer
Identifiers
PMID42427638
PMCPMC13345016
What Socratic holds
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