Evidence map›Paper›PMID 42427642›Full record

ArticlebioRxiv : the preprint server for biology2026

CAGE-TRX expands the scope of time-resolved crystallography through genetically encoded active-site photocaging.

Clyde A Smith, Ailiena O Maggiolo, Chasity Janosko, Maura E Charette, Nilakshi Paul, Marta Toth, Guillermo Calero, Sierra M Carr, Silvia Russi, Sergei B Vakulenko and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Clyde A SmithStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, CA 94025, USA.ORCID 0000-0002-1885-1511
Ailiena O MaggioloStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, CA 94025, USA.
Chasity JanoskoDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Maura E CharetteDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Nilakshi PaulDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Marta TothDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Guillermo CaleroDepartment of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Sierra M CarrStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, CA 94025, USA.
Silvia RussiStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, CA 94025, USA.
Sergei B VakulenkoDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Alexander DeitersDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Aina E CohenStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, CA 94025, USA.

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Carbapenemase-Stable Carbapenem Antibiotics for Treatment of Multidrug-Resistant Acinetobacter baumannii InfectionsR01AI155723 · NIAID · UNIVERSITY OF NOTRE DAME · PI BUYNAK, JOHN D, VAKULENKO, SERGEI · 2021 to 2025
$3.9M
"On the Fly" Time Resolved Cryo-EM Studies of Intermediate HIV-1 RT Transition StatesR01AI175067 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Guillermo Alberto Calero, Alexander Deiters · 2022 to 2026
$3.8M
NIAID NIH HHS R01 AI155723NIAID NIH HHS R01 AI175067NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

We present CAGE-TRX, a broadly applicable time-resolved strategy for

Identifiers

PMID42427642
PMCPMC13345100

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.