Evidence map›Paper›PMID 42427677›Full record

ArticlebioRxiv : the preprint server for biology2026

Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations.

Ronald G Jones, Pieter J Koopmans, Nathan Serrano, Ana Regina Cabrera, Francielly Morena, Toby L Chambers, Ruth Walters, Agnieszka K Borowik, Michael E Taylor, Ross P Wohlgemuth and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ronald G JonesMolecular Muscle Mass Regulation (M3R) Laboratory, Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.
Pieter J KoopmansMolecular Muscle Mass Regulation (M3R) Laboratory, Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.
Nathan SerranoMolecular Muscle Mass Regulation (M3R) Laboratory, Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.
Ana Regina CabreraMolecular Muscle Mass Regulation (M3R) Laboratory, Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.
Francielly MorenaDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Toby L ChambersMolecular Muscle Mass Regulation (M3R) Laboratory, Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.
Ruth WaltersMolecular Muscle Mass Regulation (M3R) Laboratory, Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.
Agnieszka K BorowikAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Michael E TaylorAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Ross P WohlgemuthCenter for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
Jazmine A Eccles MillerSchool of Human Environmental Sciences, University of Arkansas, Fayetteville, AR, USA.
Abigail L ZirbelSchool of Human Environmental Sciences, University of Arkansas, Fayetteville, AR, USA.
Lea C RangeDepartment of Anatomy, Physiology, and Pharmacology, Auburn University, Auburn, Alabama, USA.
Sebastian EdmanDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Ferdinand von WaldenDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Christopher S FryCenter for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
Joanna L FiddlerSchool of Human Environmental Sciences, University of Arkansas, Fayetteville, AR, USA.
Benjamin F MillerAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Ahmed IsmaeelDepartment of Anatomy, Physiology, and Pharmacology, Auburn University, Auburn, Alabama, USA.
Yuan WenCenter for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
Kevin A MurachMolecular Muscle Mass Regulation (M3R) Laboratory, Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.ORCID 0000-0003-2783-7137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite decades of study, MYC's physiological role in adult tissues remains obscured by the models used to investigate it. Most work relies almost exclusively on chronic or constitutive MYC induction that recapitulates the sustained activity found in tumorigenesis and expectedly produces pathological outcomes. What has gone largely untested is how MYC operates when induced in a controlled and physiologically relevant manner, as it is during adaptive processes such as exercise. Using a recombination-independent strategy in adult skeletal muscle, transient MYC bursts drive coordinated hypertrophic-metabolic reprogramming followed by a shift in myosin fiber type, recapitulating adaptations characteristic of concurrent endurance and resistance training. A single pleiotropic transcription factor governing several aspects of muscle health reframes perspectives on a gene understood almost entirely in the context of pathology. We uncover a previously unrecognized muscle-specific role for MYC in controlling muscle cell composition and present a multi-timepoint multi-omic resource for interrogating MYC: data.myoanalytics.com/study/myc_transient/gene.

Indexed as

fiber type transitioningHypertrophyoncogeneproteomicsRNA sequencingsnRNA-seq

Identifiers

PMID42427677
PMCPMC13344976

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.