Evidence map›Paper›PMID 42427688›Full record

ArticlebioRxiv : the preprint server for biology2026

N-Acetylaspartate Synthesis as a Thermodynamic Relief Mechanism for Mitochondrial Aspartate Aminotransferase.

Narayanan Puthillathu, John R Moffett, Barbara S Slusher, Aryan M Namboodiri

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Narayanan PuthillathuBiophysics Graduate Program, The Ohio State University, Columbus, Ohio, United States.
John R MoffettDepartment of Anatomy, Physiology and Genetics and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.ORCID 0000-0002-2804-4553
Barbara S SlusherJohns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.ORCID 0000-0001-9814-4157
Aryan M NamboodiriDepartment of Anatomy, Physiology and Genetics and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Funding

Development of NAT8L inhibitors for the Treatment of Canavan DiseaseR61NS136652 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SLUSHER, BARBARA STAUCH, TSUKAMOTO, TAKASHI · 2024 to 2025
$790k
NINDS NIH HHS R61 NS136652
6 · The paper itself

Abstract

N-acetylaspartate (NAA) is the most abundant neuron-enriched acetylated metabolite in the mammalian brain, but its metabolic purpose remains unresolved. We developed a simplified kinetic model of mitochondrial aspartate metabolism to test whether NAA synthesis by aspartate N-acetyltransferase (ASPNAT) acts as a thermodynamic "relief valve" for mitochondrial aspartate aminotransferase (AAT) under the low-oxaloacetate (OAA) conditions expected in neuronal mitochondria. In the mitochondrial-compartment model, ASPNAT lowered steady-state mitochondrial aspartate from 141 to 105

Indexed as

adipose tissueAralar1ASPNATGOT2malate-aspartate shuttlemitochondrial modelingNAANAT8L

Identifiers

PMID42427688
PMCPMC13345057

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.