ArticlebioRxiv : the preprint server for biology2026
Genetically Encoded Melanin as a Photostable Scattering Contrast for Whole-Brain Tomography.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Large-scale brain imaging has traditionally depended on fluorescent reporters, but challenges like photobleaching and inconsistent signals hinder quantitative analysis in intact tissues. In response, we present MelaCAST (melanin-based scattering CAST imaging), a novel genetically encoded scattering method for whole-brain visualization. Using AAV to deliver tyrosinase allows for cell-type-specific melanin synthesis, providing a stable intracellular scattering contrast across the mouse brain. Combining tissue clearing with scattering tomography, MelaCAST offers non-photobleaching, high-throughput volumetric imaging of genetically targeted cell populations in intact brains. This technique establishes melanin as a genetically encoded scattering reporter and broadens whole-organ imaging capabilities beyond traditional fluorescence methods.
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Registered trials
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