Evidence map›Paper›PMID 42427771›Full record

ArticlebioRxiv : the preprint server for biology2026

The

Joseph E Zemke, Guangming Huang, Emma Starr, Matthew Broder, Jacob Marsh, Arun Renganathan, Bridget Phillips, Thomas W Marsh, Miguel Minaya, Carlos Cruchaga and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joseph E ZemkeDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-9730-1421
Guangming HuangDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Emma StarrDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Matthew BroderDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Jacob MarshDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-3576-6949
Arun RenganathanDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-6722-8136
Bridget PhillipsDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-5261-689X
Thomas W MarshDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-8565-3788
Miguel MinayaDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-2573-6087
Carlos CruchagaDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-0276-2899
Abhirami K IyerDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-1914-6045
Dominantly Inherited Alzheimer Network
Celeste M KarchDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-6854-5547

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal ProteasesU54NS123985 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A., KAO, AIMEE · 2021 to 2025
$9.0M
Targeting Tau Proteoforms in Frontotemporal DementiaRF1NS110890 · NINDS · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2021 to 2021
$1.8M
NCATS NIH HHS UL1 TR002345NIA NIH HHS P30 AG066444NIA NIH HHS U19 AG032438NINDS NIH HHS RF1 NS110890NINDS NIH HHS U54 NS123985
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are increasingly implicated in neurodegenerative disease, yet their roles in tauopathy remain poorly understood. Here, we defined the lncRNA landscape across iPSC-derived neurons, astrocytes, and microglia harboring the frontotemporal dementia-associated

Identifiers

PMID42427771
PMCPMC13344995

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.