Evidence map›Paper›PMID 42427802›Full record

ArticleResearch (Washington, D.C.)2026

Piezo1 Impairs Endothelial Barrier and Drives Aortic Aneurysm and Dissection via STAT3-Dependent Activation of the CCL2-CCR2 Axis.

Kehui Yang, Yang Liu, Xiaoran Huang, Dehui Hou, Han Du, Jingwen Wang, Hongwei Yue, Yunyun Guo, Sumei Cui, Huidan Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kehui YangDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Yang LiuDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Xiaoran HuangDepartment of Emergency Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Dehui HouDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Han DuDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Jingwen WangDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Hongwei YueDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Yunyun GuoDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Sumei CuiDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Huidan ZhangDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Yijun SunDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.
Xin LiDepartment of Emergency Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Jun RenDepartment of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Feng XuDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-4670-3727
Yuguo ChenDepartment of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial cells (ECs) sense hemodynamic forces and critically influence aortic aneurysm and dissection (AAD) development. However, the possible contribution of the mechanical sensor Piezo1 to AAD remains elusive. Single-cell mRNA sequencing identified Piezo1 as the most up-regulated mechanical sensor in ECs from AAD model mice. Immunofluorescence and immunoblotting confirmed markedly increased Piezo1 protein in human and mouse AAD samples. Disturbed flow induced by abdominal aortic constriction plus Angiotensin II up-regulated Piezo1 expression and AAD incidence, whereas Piezo1 inhibition attenuated both. Moreover, EC-specific Piezo1 deficiency was sufficient to suppress β-aminopropionitrile- and Ang II-induced AAD formation in mice. Mechanistically, we discovered the disturbed shear stress-induced opening of the endothelial barrier via Piezo1 and subsequent Ca

Identifiers

PMID42427802
PMCPMC13346660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.