ArticleResearch square2026
Isolated Nocturnal Hypertension and Target Organ Damage: A SHIP-AHOY Ancillary Study.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
12 authors.
Funding
Abstract
Background: Isolated nocturnal hypertension (INH) and its relationship to target organ damage (TOD) is poorly studied in pediatrics. This study aims to examine the epidemiology of INH in the Study of Hypertension in Pediatrics, Adult Hypertension Onset in Youth (SHIP-AHOY) cohort and its association with TOD. INH is hypothesized to be associated with an increased risk of TOD. Methods: Data were obtained from SHIP-AHOY participants. Primary exposure was INH, defined using static thresholds (wake < 130/80, sleep ≥ 110/65) and using the 95th percentile for ambulatory blood pressure (BP). Primary outcome was left ventricular hypertrophy (LVH), defined as left ventricular mass index > 38.6 g/m Results: Using static thresholds, INH was present in 19.7% of adolescents, 61% due to systolic BP only. Age and height were greater in INH than normotension (16.1v15.4 years, P = 0.008) (168.9v166.4 cm, P = 0.036). Other demographics and anthropometric variables did not significantly differ. INH had lower estimated glomerular filtration rate (96.3v100.3 ml/min/1.73m Conclusions: INH is prevalent and associated with 2.7-fold adjusted odds of LVH compared to normotension in adolescents. Longitudinal studies are needed to characterize long-term implications of INH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.