Evidence map›Paper›PMID 42428101›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Sugar sweetened and artificially sweetened beverages, fruit and vegetable juices and cancer risk: a World Cancer Research Fund International Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.

Ahmad Jayedi, Georgios Markozannes, Sayada Zartasha Kazmi, Margarita Cariolou, Rita Vieira, Sonia Kiss, Katia Balducci, Eirini Pagkalidou, Sofia Cividini, Dagfinn Aune and 31 more

Abstract readPreprint
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In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Ahmad JayediDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0003-4231-3147
Georgios MarkozannesDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0001-8481-579X
Sayada Zartasha KazmiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0002-9267-3637
Margarita CariolouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0003-2660-7866
Rita VieiraDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.
Sonia KissDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.
Katia BalducciDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.
Eirini PagkalidouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0002-8655-7293
Sofia CividiniDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0003-2705-9224
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0002-4533-1722
Darren C GreenwoodLeeds Institute for Data Analytics, University of Leeds, Leeds, UK.ORCID 0000-0001-7035-3096
Laure DossusNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0003-2716-5748
Emma FontvieilleNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0001-5488-9317
Nahid AhmadiNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0001-8144-2764
Yahya Mahamat-SalehNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-5892-8886
Amanda J CrossDepartment of Surgery and Cancer, Imperial College London, London, UK.ORCID 0000-0002-0893-2377
Marc J GunterCancer Epidemiology and Prevention Research Unit, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-5472-6761
Shalini Jayasekar ZürnKnowledge, Advocacy and Policy, Union for International Cancer Control, Geneva, Switzerland.
Christian C AbnetMetabolic Epidemiology Branch (MEB), Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, United States.ORCID 0000-0002-3008-7843
Pietro FerrariHead, Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0001-9358-7338
Vanessa L Z Gordon-DseaguWorld Cancer Research Fund International, London, UK.ORCID 0000-0003-1867-2238
Kristy MaskellWorld Cancer Research Fund International, London, UK.
Christelle ClaryWorld Cancer Research Fund International, London, UK.ORCID 0000-0001-5959-5043
Helen CrokerWorld Cancer Research Fund International, London, UK.ORCID 0000-0002-7247-6599
Panagiota MitrouWorld Cancer Research Fund International, London, UK.
Elio RiboliWorld Cancer Research Fund International, London, UK.ORCID 0000-0001-6795-6080
Monica BaskinMassey Comprehensive Cancer Center, USA.ORCID 0000-0002-5544-0412
Rajiv ChowdhuryDepartment of Global Health, Florida International University, Miami, Florida, USA.ORCID 0000-0003-4881-5690
Mia GaudetTrans-Divisional Research Program (TDRP), Division of Cancer Epidemiology Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health, Rockville, MD 20850, United States.ORCID 0000-0002-6429-4007
Edward GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0009-0003-9117-569X
Ellen KampmanDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.ORCID 0000-0002-8606-7075
Sarah J LewisPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0003-4311-6890
Anne M MayUniversity Medical Centre Utrecht, Julius Centre for Health Sciences and Primary Care, Utrecht, The Netherlands.
Yikyung ParkDivision of Public Health Sciences, Washington University School of Medicine, Washington University in St.Louis, St Louis, USA.ORCID 0000-0002-6281-489X
Tobias PischonMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine, Berlin, Germany.ORCID 0000-0003-1568-767X
Gianluca SeveriCESP U1018, U.Paris-Saclay, UVSQ, INSERM, France.
Lynette HillPublic Representative.
Matty P WeijenbergDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-1695-4768
John KrebsDepartment of Biology, University of Oxford, Oxford, UK.
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.
Doris S M ChanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London.ORCID 0000-0002-0198-1897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sugar sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and fruit and vegetable juices are consumed worldwide, yet their associations with cancer remain unclear. Methods: Within World Cancer Research Fund International's Global Cancer Update Programme (CUP Global), we conducted a systematic review by searching PubMed and Embase until September 2024 for cohort studies of SSBs, ASBs, and juices and cancer risk. Meta-analyses were conducted to calculate the relative risks (RRs) and 95% CIs per 1 serving/day (355 mL for SSBs/ASBs; 177 mL for juices). Evidence was graded by the CUP Global Expert Panel. The CUP Global standard protocol was registered at: https://osf.io/7utbm/. Findings: We identified 158 publications from 51 cohorts. There was evidence of a probable causal positive association for SSBs, including carbonated SSBs, with pancreatic cancer incidence (RR 1.09 [95% CI 1.01-1.16]; I Interpretation: This review provides evidence supporting probable causal associations of SSBs with pancreatic and colorectal cancers, and of orange juice with skin cancers, with additional suggestive evidence for SSBs with other obesity-related cancers, extending concerns about sugary drink consumption beyond cardiometabolic health to cancer risk.

Identifiers

PMID42428101
PMCPMC13345450

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.