Evidence map›Paper›PMID 42428130›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Genetic and transcriptomic determinants of disseminated coccidioidomycosis identify a founder variant in

Samantha L Jensen, Sarah J Spendlove, Alexis V Stephens, Zhenjie Jin, Varada Abhyankar, Kangcheng Hou, Rachel Mester, Traci Toy, Eleazar Eskin, George R Thompson and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Samantha L JensenDepartment of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-4090-304X
Sarah J SpendloveBioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-5439-0863
Alexis V StephensDepartment of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-5979-6838
Zhenjie JinDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0009-0009-2609-8206
Varada AbhyankarDepartment of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0003-2719-4901
Kangcheng HouBioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.ORCID 0000-0001-7110-5596
Rachel MesterDepartment of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-6498-7727
Traci ToyDepartment of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0009-0005-1729-816X
Eleazar EskinDepartment of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0003-1149-4758
George R ThompsonUC Davis Center for Valley Fever, UC Davis, Davis, CA, USA.ORCID 0000-0001-8518-5750
Royce H JohnsonDepartment of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Arash HeidariDignity Health, Bakersfield Memorial Hospital, Bakersfield, CA, USA.ORCID 0000-0003-1091-348X
Rasha KuranDepartment of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-3189-2596
Paul KrogstadDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, Los Angeles, CA, USA.ORCID 0000-0001-6191-6213
Bogdan PasaniucDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0227-2056
Harold PimentelDepartment of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0001-8556-2499
Manish J ButteDepartment of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-4490-5595
Valerie A ArboledaDepartment of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-9687-9122

Funding

Innate immune mechanisms of the host response to CoccidioidesU19AI166059 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MANISH J BUTTE · 2022 to 2026
$10.0M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
NHGRI NIH HHS T32 HG002536NIAID NIH HHS U19 AI166059
6 · The paper itself

Abstract

Coccidioidomycosis, also known as Valley Fever, is a fungal disease endemic to the Americas that kills hundreds annually, yet the host factors that lead to increased risk of life-threatening dissemination of coccidioidomycosis remain poorly understood. We assembled the largest comprehensively sequenced coccidioidomycosis cohort to date, comprising 795 individuals with laboratory confirmed coccidioidomycosis and clinical disease severity phenotyping, many with paired whole blood genomic and transcriptomic data. Individuals with greater than 50% African genetic ancestry have increased risk for disseminated coccidioidomycosis (DCM) cases (OR=13.37, p=1.08×10

Identifiers

PMID42428130
PMCPMC13345576

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.