ArticleFrontiers in oncology2026
MRI biomarkers of primary CNS lymphoma outcome after MATRix: real world performance.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Introduction: Despite treatment advances, accurate prognostication for patients with newly diagnosed primary central nervous system lymphoma (PCNSL) remains unsatisfactory. This retrospective cohort study evaluated whether T1 contrast-enhanced (T1CE) tumour volume and apparent diffusion coefficient (ADC) metrics on magnetic resonance imaging (MRI) predict survival in PCNSL patients treated uniformly with MATRix chemotherapy. Methods: Sixty-five patients underwent pre-treatment MRI with volumetric and diffusion analysis. T1CE tumour volume, ADCmean, ADCmin and normalised diffusion parameters were assessed. Survival outcomes were analysed using univariate Cox regression for overall survival (OS) and progression-free survival (PFS), including disease-specific endpoints. Results: None of the tested imaging variables were significantly associated with OS or PFS, including T1CE tumour volume and ADC measures. Baseline T1CE and diffusion biomarkers did not predict survival in MATRix-treated PCNSL. Discussion: These results highlight limitations of standard MRI techniques for prognostication underscoring the need for integrated multiparametric models incorporating imaging and biological data to improve outcome prediction.
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