Evidence map›Paper›PMID 42428252›Full record

ArticleEnvironmental health perspectives2026

The Role of Gut Microbiota in the Association between Air Pollution and Cognitive Function in Older Adults.

Wenhao Qi, Mengmeng Kong, Xia Meng, Zhonghan Sun, Zhendong Mei, Yanni Pu, Xiaofeng Zhou, Qichu Wang, Jian-Ge Qiu, Bing-Hua Jiang and 6 more

Abstract read
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Article in Environmental health perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wenhao QiState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Mengmeng KongState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Xia MengSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.ORCID 0000-0002-0751-1722
Zhonghan SunState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Zhendong MeiDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States.
Yanni PuState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Xiaofeng ZhouState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Qichu WangState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Jian-Ge QiuThe Academy of Medical Science, Zhengzhou University, Zhengzhou 450001, China.
Bing-Hua JiangThe Academy of Medical Science, Zhengzhou University, Zhengzhou 450001, China.
Jie ShenSchool of Public Health, Zhejiang University, Zhejiang 310058, China.
Changzheng YuanSchool of Public Health, Zhejiang University, Zhejiang 310058, China.
John S JiVanke School of Public Health, Tsinghua University, Beijing 100084, China.
Xiaofeng WangState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Haidong KanSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.ORCID 0000-0002-1871-8999
Yan ZhengState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences and Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0000-0003-1129-3147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowing evidence links air pollution to cognitive dysfunction in older adults. The gut microbiome and circulating metabolites present an important yet unexplored pathway given their crucial role in the gut-brain axis.

objectivesWe aimed to explore the potential roles of gut bacteria, fungi, microbial functional potentials, and circulating metabolites in the association of residential PM

methodsWe analyzed gut microbiome data from 1,027 older adults using metagenome and internal transcribed spacer sequencing to profile bacterial and fungal taxa, functional pathways, and enzyme abundances. Targeted metabolomics quantified 195 circulating metabolites, such as amino acids and organic acids. Annual average ambient PM

resultsHigher PM

conclusionsOur findings highlight the role of the gut microbiome and microbial metabolites in mediating the detrimental impact of air pollution on cognitive health in older adults, providing new insights into the underlying etiology for future hypothesis generation.

Indexed as

Air PollutantsAir PollutionCognitionCognitive DysfunctionEnvironmental ExposureGastrointestinal MicrobiomeAgedFemaleHumansMaleOzoneParticulate MatterAir PollutantsOzoneParticulate Matter

Identifiers

PMID42428252
PMCPMC13347636

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.