Evidence mapPaperPMID 42428346Full record

ReviewOncology letters2026

New and emerging strategies for targeting cancers: Challenges and opportunities (Review).

Sreenivasa R Chinni, Arun K Rishi, Kaladhar B Reddy

Abstract readReview
In one paragraph

Review in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sreenivasa R ChinniDepartment of Urology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Arun K RishiDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Kaladhar B ReddyDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Funding

BLRD VA I01 BX004931BLRD VA IK6 BX004015
6 · The paper itself

Abstract

Despite improvements in treatment strategies for cancer patients, the response to treatment by chemotherapy or immunotherapy has benefited a small percentage of cancer patients, depending on tumor histology and other host factors. The mechanism of resistance is poorly understood because cancer cells exhibit extensive plasticity, enabling them to acquire resistance to chemo- and immunotherapy. This review summarizes the current understanding of interactions between chemo- and immunotherapy and their targets, including recent advancements in the regulatory mechanisms that control chemo- and/or immunotherapy response and resistance in cancer. Furthermore, a variety of chemotherapy and/or immunotherapies are discussed, along with recent developments aimed at preventing resistance and relapses following treatment, with a focus on upcoming initiatives to improve the efficacy of chemo- and immunotherapy for cancer patients.

Indexed as

acquired resistancecancerscancer stem cellsimmunotherapyintratumor heterogeneityintrinsic resistancetherapeutic resistance

Identifiers

PMID42428346
PMCPMC13347181

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.