ArticleAging medicine (Milton (N.S.W))2026
The Spectrum of Biopsy-Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study.
Article in Aging medicine (Milton (N.S.W)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the longitudinal pathological changes in the spectrum of biopsy-proven renal diseases among elderly patients over the past 20 years at a single center in China. Methods: We retrospectively enrolled patients aged ≥ 60 years who underwent renal biopsy at Beijing Hospital between January 2005 and December 2024. Patients were stratified into four 5-year periods (2005-2009, 2010-2014, 2015-2019, and 2020-2024) based on biopsy date. The frequency and distribution of biopsy-proven renal diseases across these periods were analyzed. Results: A total of 594 elderly patients were included, accounting for 29.2% of all native biopsies in our cohort. The mean age was 67.9 ± 5.7 years, with a male-to-female ratio of 1.4:1. The proportion of elderly patients undergoing renal biopsy increased significantly across the four periods (19.1%, 22.5%, 33.9%, 38.9%; Conclusions: The utilization of renal biopsy in elderly patients has increased significantly over the past two decades. While NS remains the most common indication, a notable rise in biopsies for CKD has been observed. The pathological spectrum has undergone a significant shift, characterized by a dramatic decrease in PGN (especially MN) and a continuous increase in SGN (predominantly DN and HTN). The predominance shifted to SGN over PGN in biopsy-proven renal diseases among the elderly in the most recent period.
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