ArticleAging medicine (Milton (N.S.W))2026
The Effect of Resistance Training and Ursolic Acid on the PI3K-AKT-mTOR Pathway in Aged Diabetic Rats: A Comparative Study.
Article in Aging medicine (Milton (N.S.W)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Sarcopenia, characterized by age-related muscle loss, worsens in diabetes due to anabolic resistance. Ursolic acid (UA), a natural compound with anabolic and anti-catabolic effects, may mitigate sarcopenia by enhancing anabolic pathways. This study examined the effects of 8 weeks of resistance training and UA supplementation on PI3K-AKT-mTORC1 pathway proteins in muscle tissue of aged diabetic rats. Methods: Fifty 21-month-old Wistar rats were divided into five groups: healthy control, diabetic control, diabetic + resistance training, diabetic + UA, and diabetic + resistance training + UA. Type 2 diabetes was induced using a high-fat diet and low-dose STZ. Resistance training consisted of 8 weeks of ladder climbing at 60% MVCC, 5 days per week. UA was administered daily to the UA and combination groups. Protein expression was analyzed using Western blot. Results: AKT and mTORC1 or phosphorylated AKT levels did not differ significantly across groups. However, dephosphorylated PI3K ( Conclusion: Diabetes reduces PI3K and mTORC1 protein expression. Resistance training or UA alone improved mTORC1 expression, while their combination enhanced both PI3K and mTORC1, suggesting synergistic anabolic benefits. Combining UA with resistance training may counteract diabetes-induced muscle loss.
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