ArticleHealth science reports2026
Oral Microbiota and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study Based on East Asian Ethnicity.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: The "oral-microbiota-brain axis" has been hypothesized to contribute to Alzheimer's disease (AD) pathogenesis, but causal evidence remains limited. We performed a bidirectional Mendelian randomization (MR) study to investigate potential genetic causality between oral microbiota and AD in East Asians. Methods: Two-sample MR integrated genome-wide data from 2984 Chinese participants (saliva/tongue dorsum microbiomes) and 7036 Japanese participants (3962 AD cases/4074 controls). Genetic instruments were selected using pragmatically moderated significance thresholds (forward: Results: Forward MR identified 12 candidate causal taxa: five with risk-increasing associations (e.g., Conclusion: This study provides genetic evidence consistent with a bidirectional relationship between oral microbiota and AD in East Asians, nominating 15 microbial taxa as candidates for further investigation. The implicated biological pathways offer hypotheses for mechanistic links via the oral-microbiota-brain axis. These findings advance the etiological understanding of AD and highlight priority targets for future experimental and clinical validation.
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